iELM Search

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PTMs crosstalk: Crosstalk between phosphorylation and caspase cleavage in apoptosis

PTMs govern cell fate: Ubiquitin, SUMO, and Phosphate governs cell fate

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Please bear in mind the prediction programs have a false positive rate and all results should be assessed with biological context in mind.

Query a single protein: protein iELM

e.g. EPS15_HUMAN; SOS1_HUMAN; P25054

Please choose database your ID is from:

Please choose domains search method:

iELM HMMs are trained to recognise linear motif-binding domains based on annotation of known PDB structures and literature searches. This is updated regularly but poorly-studied domains may be missed. If so, Pfams HMMs can be used. These HMMs will identify all globular domains of a particular type but will not take into account the specificity linear motifs often have for sub-groups of a domain family.For more information, please click here

Only human IDs work at present. More species will be added in the near future.

Query a protein interaction network: proteomic ielm

e.g. example 1; example 2

Please choose database your IDs are from:

Please choose domains search method:

iELM HMMs are trained to recognise linear motif-binding domains based on annotation of known PDB structures and literature searches. This is updated regularly but poorly-studied domains may be missed. If so, Pfams HMMs can be used. These HMMs will identify all globular domains of a particular type but will not take into account the specificity linear motifs often have for sub-groups of a domain family. For more information, please click here

There is a limit of 75,000 interactions for a tabulated list or 400 IDs for all-against-all search.
Only human IDs work at present. More species will be added in the near future

iELM^1.0 predicts linear motif mediated interactions of ELM annotated functional classes. This form allows a user to search their protein of interest for short linear motif-mediated interactions within the high-quality protein-protein association data extracted from the STRING database

Proteomic iELM searches a users protein-protein interaction dataset for short linear motif mediated interactions. The user may input data in two ways:
1) A list of protein with a seperate ID on each line. For example press here
2) Two proteins per a line seperated by a space (as in the example). The program will only test specified associations. For example press here

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Interesting.websites

Interesting.Articles

Query a single protein: protein iELM

Query a protein interaction network: proteomic ielm